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However, contributed by the accumulated indissolvable parent drug, the C max value of MBZ-1 tragacanth was nearly 6 times of the new formulation in the intestine. On the other hand, MBZ-OS promoted more MBZ into the systemic circulation. It was found that the C max and AUC 0-t values of MBZ-OS in liver and kidney were not changed as much as in plasma. As the crucial metabolism and elimination organs, liver and kidney might clear away MBZ by their corresponding functions.
However, in lung, spleen and brain, C max and AUC 0-t of MBZ-OS were significantly increased than MBZ-1 tragacanth.